Dr. Getrude Cynthia Sitolo

Dr. Getrude Cynthia Sitolo

Author

Physics & Biochemical Sciences

5 publications

Gertrude Cynthia Sitolo graduated with Bachelor of Science degree from University of Malawi – The Polytechnic (2006) and earned a Master of Science degree in Food Science from The University of Melbourne, Australia in 2013. She holds a PhD in Food Science and Nutrition from Hiroshima University, Jap...

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Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production

Journal Article
Published 1 year ago, 394 views
Author
Dr. Getrude Cynthia Sitolo
Co-authors
Aya Mitarai, Precious Adedayo Adesina, Yoshinari Yamamoto, Takuya Suzuki
Abstract
Short chain fatty acids (SCFAs), the microbial metabolites of fermentable dietary fibers exert
multiple beneficial effects on mammals including humans. We examined the effects of
fermentable dietary fibers on suppressor of cytokine signaling 1 (SOCS1), a negative regulator
of inflammatory signaling, on the intestinal epithelial cells of the mouse colon and human
intestinal Caco-2 cells, specifically focusing on the role of SCFAs. Feeding fermentable fibers,
guar gum (GG) and partially hydrolyzed GG (PHGG) increased SOCS1 expression in the colon
and the cecal pool of some SCFAs including acetate, propionate, and butyrate. The antibiotic
administration abolished the GG-mediated SOCS1 expression in the colon. In Caco-2 cells,
butyrate, but not other SCFAs, increased SOCS1 expression. Taken together, fermentable fibers
such as GG and PHGG upregulate the colonic SOCS1 expression, possibly through the
increased production of butyrate in mice and can be a potential tool in the fight against
inflammatory diseases.
Year of Publication
2020
Journal Name
Bioscience, Biotechnology, and Biochemistry
Volume
84
Issue
11
Page Numbers
pp.2337-2346
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