While Health Management Information Systems (HMIS) at the national level in Malawi is integrated, separate health information subsystems operate independently at the district level. For instance, computerized Information Systems, such as District Health Information System (DHIS) and Drug Logistics Management Information System (LMIS) operate as separate independent systems at the district level. Findings reveal that integration at district level can be implemented using two possible strategies, namely (1) integration of work practices and (2) integration of databases. Some social implications of work practice integration are enhanced communication, development of personnel skills and experience in integrated reporting, as well as encourage teamwork. The integration of technology can result in interconnectivity and/or interoperability of database software. The paper discusses social and technical implications of integrating information systems in the healthcare at the district level in Malawi with DHIS and Drug LMIS as examples.